Quantitative analysis of vessels with smooth muscle layer in astrocytic tumors: correlation with histological grade and prognostic significance.

摘要: Angiogenesis plays an important role in the progression of astrocytic tumors and its evaluation is a major prognostic factor. Although form proliferating vessels ranges from fine capillaries to well-developed vascular structures with smooth muscle layer, characteristics cells (SMCs) are not understood detail. We therefore examined density, size shape tumor vessels, as well CD34-immunoreactive (CD34-Vs) or a-smooth actin-immunoreactive (SMA-Vs) 46 primary astrocytomas (grade II diffuse astrocytomas, n=11, grade III anaplastic n=15, IV glioblastomas, n=20) normal brain tissues 10 autopsies. also expression high molecular weight caldesmon (h-CD, marker contractile phenotype muscle) platelet-derived growth factor receptor s (PDGFR-s). The SMA-Vs were significantly more dense larger than III, whereas those CD34-Vs did differ between IV. Changes correlated histological grading. h-CD was reduced, that PFGFR-s increased grade-astrocytomas. Kaplan-Meier analysis indicated density SMA-Vs, both CD34 PDGFR-s significant factors. These findings suggest associated these provide useful information for diagnosis survival patients types tumors.