Morphometric study of microvessels in primary CNS tumors and its correlation with tumor types and grade

摘要: Abstract Introduction Alterations of microvasculature are integral to CNS neoplasia, and a diagnostic feature high-grade gliomas. The objectives this study were two fold: First, correlate morphometrically measured microvessel density (MVD), caliber (VC), percentage total area (%TVA) with WHO histologic grade in various types primary tumors. Second, evaluate if such correlation could be further refined by using mathematical derivatives parameters namely coefficient variation VC (COofVC), cross-sectional (VCSA), VCSA (%TVCSA). Materials methods Various assessed variety 30 tumors as consecutively encountered routine surgical pathology practice including gliomas, meningiomas others image morphometry CD34-immunostained sections. We introduced novel method effectively determining VC. Results correlated tumor type grade. Appropriate statistical analysis was performed. Microvessel characteristics, especially (p  Conclusion Tumor grades positively all parameters, %TVCSA displaying the best. %TVA weaker than mainly due impact MVD. These findings emphasize value our best illustrated its derivative (an indicator blood flow), addition well-recognized MVD prognostication. Multiple regressions provided Morphometric microvessels facilitates better understanding grade, progression overall prognosis.