Correlation of biomechanics to tissue reaction in aortic aneurysms assessed by finite elements and [18F]–fluorodeoxyglucose–PET/CT

摘要: Mechanobiological interactions are essential for the adaption of cardiovascular system to altered environmental and internal conditions, but poorly understood with regard abdominal aortic aneurysm (AAA) pathogenesis, growth rupture. In present study, we therefore calculated mechanical AAA quantities using nonlinear finite element methods correlated these [18F]-fluorodeoxyglucose (FDG)-metabolic activity in wall detected by positron emission tomography/computed tomography (PET/CT). The interplay between mechanics FDG-metabolic was analyzed terms maximum values three-dimensional spatial relationship, respectively. Fluorodeoxyglucose-positron (FDG-PET/CT) data sets n = 18 patients were studied. Maximum FDG-uptake (SUV max ) varied from 1.32 4.60 (average SUV 3.31 ± 0.87). stresses strains ranged 10.0 64.0 N∕cm(2) (38.2 13.8  N∕cm(2)) 0.190 0.260 (0.222 0.023), significantly stress strain stress: r 0.71, p 0.0005; strain: 0.66, 0.0013). To evaluate interaction acting stress, element-wise correlations performed. all 2 AAAs, positive correlation obtained, Pearson's coefficient ranging -0.168 0.738 ( 0.372 0.263). results indicate that quantitatively spatially wall. It is hypothesized unphysiologically increased loading triggers biological tissue reaction, such as inflammation or regenerative processes, causing elevated activity. These findings strongly support experimental hypotheses mechanotransduction mechanisms vivo.