Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159.
作者： Tae Young Oh , Kyung Koo Kang , Byoung Ok Ahn , Moohi Yoo , Won Bae Kim
DOI: 10.1007/BF02976575
关键词: Sodium nitroprusside 、 Oral administration 、 Phenylephrine 、 Erectile dysfunction 、 Nitric oxide 、 Internal medicine 、 cGMP-specific phosphodiesterase type 5 、 Phosphodiesterase 5 inhibitor 、 Chemistry 、 Endocrinology 、 Dose–response relationship
摘要: DA-8159, a new phosphodiesterase 5 inhibitor, was assessed for its erectogenic potential by penile erection test in rats, the relaxation of isolated rabbit corpus cavernosum (CC), and estimation intracavernous pressure (ICP) anesthetized dog. Oral administration DA-8159 (0.3 to 1 mg/kg) increased number erections rats with increasing dosage, highest index at 10 mg/kg. induced phenylephrine (PHE)-induced contractions CC decreased IC50 nitric oxide donor sodium nitroprusside (SNP) dose-dependent fashion. In pentobarbital-anesthetized dogs, intravenous (1 approximately 300 g/kg) potentiated increase ICP intracavernosal SNP dose-related manner. These findings suggest that has significant therapeutic treatment erectile dysfunction.
springer.com
sci-hub.se 参考文章(23)
R.W. Butcher, R.J. Ho, H.C. Meng, Earl W. Sutherland, Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. Journal of Biological Chemistry. ,vol. 240, pp. 4515- 4523 ,(1965) , 10.1016/S0021-9258(18)97092-4
Hoffman E, Whitehead Ed, Butler Rn, Lewis Mi, Love and sex after 60: how to evaluate and treat the impotent older man. A roundtable discussion: Part 2. Geriatrics. ,vol. 49, pp. 27- 32 ,(1994)
F. Trigo-Rocha, W. J. Aronson, M. Hohenfellner, L. J. Ignarro, J. Rajfer, T. F. Lue, Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 264, ,(1993) , 10.1152/AJPHEART.1993.264.2.H419
R.W. Butcher, Earl W. Sutherland, Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. Journal of Biological Chemistry. ,vol. 237, pp. 1244- 1250 ,(1962) , 10.1016/S0021-9258(18)60316-3
B. Holmgren, R. Urbá-Holmgren, N. Trucios, M. Zermeño, J.R. Eguíbar, Association of spontaneous and dopaminergic-induced yawning and penile erections in the rat. Pharmacology, Biochemistry and Behavior. ,vol. 22, pp. 31- 35 ,(1985) , 10.1016/0091-3057(85)90481-2
M.W. Islam, M. Tariq, A.M. Ageel, M.S. Al-Said, A.M. Al-Yhya, Effect of Salvia haematodes on sexual behaviour of male rats Journal of Ethnopharmacology. ,vol. 33, pp. 67- 72 ,(1991) , 10.1016/0378-8741(91)90163-8
Miles D. Houslay, Compartmentalization of cyclic AMP phosphodiesterases, signalling ‘crosstalk’, desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP Advances in Enzyme Regulation. ,vol. 35, pp. 303- 338 ,(1995) , 10.1016/0065-2571(94)00012-R
S.A. Taha, A.M. Ageel, M.W. Islam, O.T. Ginawi, Effect of (-)-cathinone, a psychoactive alkaloid from khat (Catha edulis Forsk.) and caffeine on sexual behaviour in rats. Pharmacological Research. ,vol. 31, pp. 299- 303 ,(1995) , 10.1016/1043-6618(95)80035-2
Robert D. Utiger, A pill for impotence. The New England Journal of Medicine. ,vol. 338, pp. 1458- 1459 ,(1998) , 10.1056/NEJM199805143382009
Larry I. Lipshultz, Injection therapy for erectile dysfunction. The New England Journal of Medicine. ,vol. 334, pp. 913- 914 ,(1996) , 10.1056/NEJM199604043341409