Efficacy of DA-8159, a new PDE5 inhibitor, for inducing penile erection in rabbits with acute spinal cord injury.
作者： BO Ahn , KK Kang , GJ Ahn , JW Kwon , WB Kim
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摘要: DA-8159 is a pyrazolopyrimidinone derivative which exhibits potent and selective phosphodiesterase type 5 (PDE5) inhibition. The aim of this study was to investigate the effects on inducing penile erection in rabbits with an acute spinal cord injury (ASCI). given either orally (1, 3, or 10 mg/kg) intravenously (0.1 0.3 conscious male albino surgical transection at L2-L4 lumbar vertebra ischemic-reperfusion SCI rabbits. Erection evaluated time-course manner by measuring length uncovered mucosa. induced dose-dependent both ASCI efficacy potentiated intravenous injection sodium nitroprusside, nitric oxide donor. Potentiation effect donor implies that can enhance erectile activity during sexual arousal. These results suggest may be useful for treating dysfunction patients SCI.
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