Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans.

摘要: Species differences in the formation of DA-8164 after intravenous and/or oral administration DA-8159 to mice, rats, rabbits, dogs and humans were investigated. After DA-8159, decreased order rabbits dogs; AUC(DA-8164)/AUC(DA-8159) ratios 0.479, 0.199, 0.0452 close 0 (DA-8164 was below detection limit dog plasma), respectively. considerable rats humans, but almost negligible AUC (or AUC(0-t))(DA-8164)/AUC AUC(0-t))(DA-8159) 2.99, 2.67, 1.39 0.0650, The above data suggested that both dogs. species for may be due involvement different CYP isozymes each a amount or activity isozyme if same is involved all species. greater than those dogs, this could first-pass (gastric, intestinal hepatic) effects as proved rats.