Pharmacokinetics of DA-8159, a new erectogenic, administered at 10:00 h versus 22:00 h in rats.

摘要: Abstract Little is known about chronopharmacokinetics of PDE V inhibitors in rats as well humans. Hence, the pharmacokinetics DA-8159 and one its metabolites, DA-8164, were investigated after intravenous oral administration at a dose 30 mg/kg administered 10:00 h versus 22:00 h rats. After 22:00 h, AUC was significantly greater (528 368 μg min/ml) due to slower CL (56.1 79.5 ml/min/kg) DA-8164 also (108 66.8 μg min/ml) possibly exposure parent drug (AUC DA-8159). slower; hence, this factor could contribute DA-8159. However, DA-8159, values both not different between 22:00 h. This decrease gastrointestinal absorption may be changes intestinal first-pass effect The above data suggested that modification dosage regimen necessary humans Further studies are needed