Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research

摘要: Mantle cell lymphoma (MCL) shares immunophenotypic and karyotypic features with chronic lymphocytic leukaemia. The latter comprises two distinct entities prognosis dependent upon immunoglobulin heavy chain (IgH) gene mutational status the presence of 11q deletion. We evaluated relevance IgH status, IgV family usage deletion in a series 42 histologically reviewed classical MCL cases to determine prognostic impact. VH3 was most common VH family, VH3-21 being frequent individual gene. Approximately 30% had somatic mutation rate higher than 2%, but only 4% ter), minimal deleted regions, at 11q22.2 11q23.2. There no association between loss rate; use could be associated better prognosis.