Bone metabolism in children with asthmatreated with inhaled beclomethasone dipropionate

摘要: Previous studies have shown that inhaled corticosteroids can affect bone metabolismin adults. A study to assess the effect of beclomethasone, 300 800 μg/day for at least 6 months (mean 25 months), was therefore undertaken in children. In part 1 study, 18 children with asthma, aged 4 17 years 10.1 years), were compared an age- and sex-matched group asthma not treated corticosterolds. 2, eight more pairs compared. Comparisons also made 61 healthy Bone mineral density measured by radiographic absorptiometry, mienral content single-photon absorptiometry dual-energy x-ray showed no significant differences. Serum levels calcium, magnesium, zinc, total alkaline phosphatase, specific parathyroid hormone, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D The activity tartrate-resistant acid a marker resorption, significantly lower beclomethasone than both control normal groups, but urine calcium excretion did differ. Patients had serum osteocalcin higher copper subjects without treatment these values. We conclude (up μg/day) does reduce mineralization or increase resorption. Effects on formation difficult because per se caused reduction osteocalcin, sensitive formation.