Is the hypertensive rat really hyperreactive?
作者： J R Sutterer , C M Stoney , M Sanfillipo
关键词: Activity level 、 Blood pressure 、 Open field 、 Stimulus (physiology) 、 Internal medicine 、 Medicine 、 Endocrinology 、 Stimulation 、 General activity
摘要: This study investigated the behavior of hypertensive-prone and nonhypertensive-prone rat strains to see whether there are differences in behavioral reactivity environmental stimulation. Of primary interest was general activity, because investigators have assumed it be an index stimulation correlated with elevation blood pressure spontaneously hypertensive rats (SHR) but not normotensive Wistar-Kyoto (WKY) rats. Therefore, activity assessed SHRs WKYs as a function walking rearing open field (Experiments 1 2) crossings shuttlebox test 3, 4, 5). Activity under constant level (Experiment 1) 3) or varying degrees 4 In shuttlebox, SHR above WKY when degree constant. However, manipulated, similar for all intensity levels, while inversely related stimulus intensity. These results suggest that may generally more active than WKYs, display greater SHRs.
sci-hub.se 参考文章(26)
Daniel J. Brackett, Daniel J. Brackett, C. G. Gunn, C. G. Gunn, Michael F. Wilson, Michael F. Wilson, Carl F. Schaefer, Carl F. Schaefer, Lifelong hyperarousal in the spontaneously hypertensive rat indicated by operant behavior The Pavlovian Journal of Biological Science : Official Journal of the Pavlovian. ,vol. 13, pp. 217- 225 ,(1978) , 10.1007/BF03002257
Daniel J. Brackett, Daniel J. Brackett, C. G. Gunn, C. G. Gunn, Michael F. Wilson, Michael F. Wilson, Carl F. Schaefer, Carl F. Schaefer, Behavioral hyperreactivity in the spontaneously hypertensive rat compared to its normotensive progenitor. The Pavlovian Journal of Biological Science : Official Journal of the Pavlovian. ,vol. 13, pp. 211- 216 ,(1978) , 10.1007/BF03002256
Margareta Hallbäck, Björn Folkow, Cardiovascular Responses to Acute Mental ‘Stress' in Spontaneously Hypertensive Rats Acta Physiologica Scandinavica. ,vol. 90, pp. 684- 698 ,(1974) , 10.1111/J.1748-1716.1974.TB05636.X
James R. Sutterer, John Perry, William de Vito, Two-way shuttle box and lever-press avoidance in the spontaneously hypertensive and normotensive rat. Journal of Comparative and Physiological Psychology. ,vol. 94, pp. 155- 163 ,(1980) , 10.1037/H0077649
D. Whitehorn, D.G. Atwater, W.C. Low, J.E. Gellis, E.D. Hendley, Independence of blood pressure and locomotor hyperactivity in normotensive and genetically hypertensive rat Behavioral and Neural Biology. ,vol. 37, pp. 357- 361 ,(1983) , 10.1016/S0163-1047(83)91501-7
Richard McCarty, Irwin J. Kopin, Alterations in plasma catecholamines and behavior during acute stress in spontaneously hypertensive and Wistar-Kyoto normotensive rats Life Sciences. ,vol. 22, pp. 997- 1005 ,(1978) , 10.1016/0024-3205(78)90365-X
Richard McCarty, Robert F. Kirby, Spontaneous hypertension and open-field behavior Behavioral and Neural Biology. ,vol. 34, pp. 450- 452 ,(1982) , 10.1016/S0163-1047(82)91903-3
Robert J. Campbell, Leo V. Di Cara, Running-wheel avoidance behavior in the Wistar/Kyoto spontaneously hypertensive rat Physiology & Behavior. ,vol. 19, pp. 473- 480 ,(1977) , 10.1016/0031-9384(77)90220-7
Richard Friedman, Ronald Leder, Junichi Iwai, Avoidance behavior and genetic predisposition to hypertension Behavioral and Neural Biology. ,vol. 32, pp. 255- 260 ,(1981) , 10.1016/S0163-1047(81)90591-4
B Falkner, G Onesti, E T Angelakos, M Fernandes, C Langman, Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hemodynamics and mental stress in adolescents. Hypertension. ,vol. 1, pp. 23- 30 ,(1979) , 10.1161/01.HYP.1.1.23