Molecular pathogenesis and therapeutic strategies of human osteosarcoma

摘要: Osteosarcoma (OS) is a devastating illness with rapid rates of dissemination and poor overall prognosis, despite aggressive standard-of-care surgical techniques combination chemotherapy regimens. Identifying the molecular mechanisms involved in disease pathogenesis progression may offer insight into new therapeutic targets. Defects mesenchymal stem cell differentiation, abnormal expression oncogenes tumor suppressors, dysregulation within various important signaling pathways have all been implicated development phenotypes. As such, variety basic science translational studies shown promise identifying novel markers modulators these disease-specific aberrancies. Born out similar investigations, emerging therapies are now undergoing phases OS clinical testing. They broadly include angiogenesis inhibitors, drugs that act on bone microenvironment, receptor tyrosine kinase immune system modulators, other radio- or chemo-sensitizing agents. forms drug delivery being developed simultaneously, possibility targeting tumors locally while minimizing systemic toxicityis seemingly more achievable than ever. In this review, we not only summarize our current understanding processes, but also shed light multitude potential strategies scientific community can use to make long-term improvements patient prognosis.