Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults.
作者： Pi-Hua Liu , Yi-Cheng Chang , Yi-Der Jiang , Wei J. Chen , Tien-Jyun Chang
DOI: 10.1210/JC.2009-0609
关键词: Insulin 、 Transmission disequilibrium test 、 Insulin resistance 、 Internal medicine 、 Biology 、 Glucose homeostasis 、 Single-nucleotide polymorphism 、 Allele 、 Endocrinology 、 Type 2 diabetes 、 TCF7L2
摘要: Objectives: The effect of TCF7L2 rs7903146 on glucose homeostasis is considered primarily due to impaired insulin secretion in European populations. Because we previously demonstrated that rs290487 near the 3′ end was significantly associated with type 2 diabetes (T2D) Taiwanese subjects, aimed investigate potential mechanisms underlying associations T2D. Methods: Eighteen single nucleotide polymorphisms (SNPs) were tested for association glucose/insulin as well other quantitative metabolic phenotypes using transmission disequilibrium test 525 adolescent twin-pairs and siblings. results further replicated 116 nondiabetic normotensive Caucasian young adults. Results: Among 18 SNPs, C allele higher 60-, 90-, 120-min concentrations (P = 0.001, 0.01, 0.02, respectively); 60- 90-min 0.01 respe...
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David Melzer, Anna Murray, Alison J Hurst, Michael N Weedon, Stefania Bandinelli, Anna Maria Corsi, Luigi Ferrucci, Guiseppe Paolisso, Jack M Guralnik, Timothy M Frayling, None, Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Medicine. ,vol. 4, pp. 34- 34 ,(2006) , 10.1186/1741-7015-4-34
Emmanuel Tubacher, Richard Hamelin, Alex Duval, Hung Bui, Gilles Thomas, Sandra Rolland, The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines Cancer Research. ,vol. 60, pp. 3872- 3879 ,(2000)
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732
S. C. Elbein, W. S. Chu, S. K. Das, A. Yao-Borengasser, S. J. Hasstedt, H. Wang, N. Rasouli, P. A. Kern, Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent Diabetologia. ,vol. 50, pp. 1621- 1630 ,(2007) , 10.1007/S00125-007-0717-X
Valeriya Lyssenko, Roberto Lupi, Piero Marchetti, Silvia Del Guerra, Marju Orho-Melander, Peter Almgren, Marketa Sjögren, Charlotte Ling, Karl-Fredrik Eriksson, Rita Mancarella, Göran Berglund, Tiinamaija Tuomi, Peter Nilsson, Stefano Del Prato, Leif Groop, None, Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes Journal of Clinical Investigation. ,vol. 117, pp. 2155- 2163 ,(2007) , 10.1172/JCI30706
Pi-Hua Liu, Yi-Der Jiang, Wei J. Chen, Ching-Chung Chang, Tso-Ching Lee, H. Sunny Sun, Lee-Ming Chuang, Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: a multivariate twin/sibling analysis. Twin Research and Human Genetics. ,vol. 11, pp. 495- 504 ,(2008) , 10.1375/TWIN.11.5.495
Q. Ren, X. Y. Han, F. Wang, X. Y. Zhang, L. C. Han, Y. Y. Luo, X. H. Zhou, L. N. Ji, Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. Diabetologia. ,vol. 51, pp. 1146- 1152 ,(2008) , 10.1007/S00125-008-1039-3
Kazuaki Miyake, Yukio Horikawa, Kazuo Hara, Kazuki Yasuda, Haruhiko Osawa, Hiroto Furuta, Yushi Hirota, Kazuya Yamagata, Yoshinori Hinokio, Yoshitomo Oka, Naoko Iwasaki, Yasuhiko Iwamoto, Yuichiro Yamada, Yutaka Seino, Hiroshi Maegawa, Atsunori Kashiwagi, Ken Yamamoto, Katsushi Tokunaga, Jun Takeda, Hideichi Makino, Kishio Nanjo, Takashi Kadowaki, Masato Kasuga, Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. Journal of Human Genetics. ,vol. 53, pp. 174- 180 ,(2008) , 10.1007/S10038-007-0231-5
J. Wang, J. Kuusisto, M. Vänttinen, T. Kuulasmaa, J. Lindström, J. Tuomilehto, M. Uusitupa, M. Laakso, Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion Diabetologia. ,vol. 50, pp. 1192- 1200 ,(2007) , 10.1007/S00125-007-0656-6
Jose C Florez, Kathleen A Jablonski, Nick Bayley, Toni I Pollin, Paul IW de Bakker, Alan R Shuldiner, William C Knowler, David M Nathan, David Altshuler, None, TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. The New England Journal of Medicine. ,vol. 355, pp. 241- 250 ,(2006) , 10.1056/NEJMOA062418