MicroRNAs: cobblestones on the road to cancer metastasis.

摘要: Cancer metastasis is the product of a multistep process during which tumor cells, responding to different intrinsic and extrinsic stimuli, detach from primary mass, invade contiguous stroma, migrate over long distance, colonize distant organs. Despite well-established role protein-coding genes behind such events, emerging evidence suggests how genetic epigenetic alterations in microRNAs equally contribute cancer metastasis. In this review, we retrace step-to-step all most salient phases dissemination process, by focusing on that specific play time cell leaves until it acquires ability form secondary tumors at sites. We also provide discussion relevant conceptual technological issues need be addressed before microRNA-based therapy might exploited clinical setting for prevention cure metastatic disease.