Mechanisms of reversal of adriamycin resistance in human ovarian carcinoma cell line by ultrasound.
作者： T. Yu , X. Huang , K. Hu , J. Bai , Z. Wang
DOI: 10.1111/J.1048-891X.2004.014039.X
关键词: Flow cytometry 、 Ovarian cancer 、 Ovarian cancer cells 、 Medicine 、 Gene expression 、 Cancer research 、 Oncology 、 Internal medicine 、 Ovarian carcinoma 、 Cell culture 、 Apoptosis 、 Ultrasound
摘要: The aim of this study was to investigate the reversal adriamycin resistance in human ovarian cancer cells by ultrasound exposure from perspectives apoptosis and mdr1 gene. Apoptosis determined flow cytometry level reverse transcription-polymerase chain reaction (RT-PCR). indexes were improved groups which exposures applied. RT-PCR did not support that insonation-decreased level. These findings suggested ultrasound-enhanced therapeutic efficacy mediated via modulating gene expression, maybe lowered thresholds for oncosis chemoresistant cells.
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