Early immunologic response and subsequent survival among malnourished adults receiving antiretroviral therapy in Urban Zambia
作者： John R Koethe , Mohammed I Limbada , Mark J Giganti , Christopher K Nyirenda , Lloyd Mulenga
DOI: 10.1097/QAD.0B013E32833B784A
关键词: Retrospective cohort study 、 Body mass index 、 Cohort 、 Surgery 、 Young adult 、 Population study 、 Pharmacotherapy 、 Medicine 、 Internal medicine 、 Population 、 Malnutrition 、 Immunology 、 Immunology and Allergy 、 Infectious Diseases
摘要: Objective—To evaluate the relationship between early CD4 + lymphocyte recovery on antiretroviral therapy (ART) and subsequent survival among low body mass index (BMI) HIV-1 infected adults. Design—Retrospective analysis of a large programmatic cohort in Lusaka, Zambia. Methods—We evaluated ART treated adults enrolled care >6 months. We stratified this study population according to WHO malnutrition criteria: normal (BMI ≥18.5 kg/m 2 ), mild (17.00-18.49), moderate (16.00-16.99), severe (<16.0). used Cox proportional hazards regression estimate risk death associated with absolute count change over first 6 months ART. To account for effect modification baseline count, weighted summary measure was calculated.
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sci-hub.se 参考文章(17)
R K Chandra, 1990 McCollum Award Lecture. Nutrition and immunity: lessons from the past and new insights into the future The American Journal of Clinical Nutrition. ,vol. 53, pp. 1087- 1101 ,(1991) , 10.1093/AJCN/53.5.1087
Benjamin H Chi, Mark Giganti, Priscilla L Mulenga, Mohammed Limbada, Stewart E Reid, Wilbroad Mutale, Jeffrey S A Stringer, CD4+ response and subsequent risk of death among patients on antiretroviral therapy in Lusaka, Zambia Journal of Acquired Immune Deficiency Syndromes. ,vol. 52, pp. 125- 131 ,(2009) , 10.1097/QAI.0B013E3181AB6D8B
Jason D. Goldman, Ronald A. Cantrell, Lloyd B. Mulenga, Bushimbwa C. Tambatamba, Stewart E. Reid, Jens W. Levy, Mohammed Limbada, Angela Taylor, Michael S. Saag, Sten H. Vermund, Jeffrey S.A. Stringer, Benjamin H. Chi, Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy AIDS Research and Human Retroviruses. ,vol. 24, pp. 1031- 1035 ,(2008) , 10.1089/AID.2008.0035
Asgeir Johannessen, Ezra Naman, Bernard J Ngowi, Leiv Sandvik, Mecky I Matee, Henry E Aglen, Svein G Gundersen, Johan N Bruun, Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania BMC Infectious Diseases. ,vol. 8, pp. 52- 52 ,(2008) , 10.1186/1471-2334-8-52
Ronald A Cantrell, Moses Sinkala, Karen Megazinni, Sibi Lawson-Marriott, Sierra Washington, Benjamin H Chi, Bushimbwa Tambatamba-Chapula, Jens Levy, Elizabeth M Stringer, Lloyd Mulenga, Jeffrey S A Stringer, A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia Journal of Acquired Immune Deficiency Syndromes. ,vol. 49, pp. 190- 195 ,(2008) , 10.1097/QAI.0B013E31818455D2
Siaka Toure, Bertin Kouadio, Catherine Seyler, Moussa Traore, Nicole Dakoury-Dogbo, Julien Duvignac, Nafissatou Diakite, Sophie Karcher, Christophe Grundmann, Richard Marlink, François Dabis, Xavier Anglaret, Aconda Study Group, Rapid scaling-up of antiretroviral therapy in 10,000 adults in Côte d'Ivoire: 2-year outcomes and determinants. AIDS. ,vol. 22, pp. 873- 882 ,(2008) , 10.1097/QAD.0B013E3282F768F8
R. E. Barth, J. T. M. van der Meer, A. I. M. Hoepelman, P. A. Schrooders, D. A. van de Vijver, S. P. M. Geelen, H. A. Tempelman, Effectiveness of highly active antiretroviral therapy administered by general practitioners in rural South Africa. European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 27, pp. 977- 984 ,(2008) , 10.1007/S10096-008-0534-2
NI Paton, S Sangeetha, A Earnest, R Bellamy, The impact of malnutrition on survival and the CD4 count response in HIV-infected patients starting antiretroviral therapy Hiv Medicine. ,vol. 7, pp. 323- 330 ,(2006) , 10.1111/J.1468-1293.2006.00383.X
Rony Zachariah, Margaret Fitzgerald, Moses Massaquoi, Olesu Pasulani, Line Arnould, Simon Makombe, Anthony D Harries, Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. AIDS. ,vol. 20, pp. 2355- 2360 ,(2006) , 10.1097/QAD.0B013E32801086B0
John R Koethe, Anna Lukusa, Mark J Giganti, Benjamin H Chi, Christopher K Nyirenda, Mohammed I Limbada, Yolan Banda, Jeffrey S A Stringer, Association between weight gain and clinical outcomes among malnourished adults initiating antiretroviral therapy in Lusaka, Zambia Journal of Acquired Immune Deficiency Syndromes. ,vol. 53, pp. 507- 513 ,(2010) , 10.1097/QAI.0B013E3181B32BAF