Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B‐cell chronic lymphocytic leukaemia: evidence of immune dysregulation
作者： Sophie Scrivener , Edward R. Kaminski , Andrew Demaine , Archie G. Prentice
DOI: 10.1046/J.1365-2141.2001.02672.X
关键词: CD154 、 CD28 、 CD8 、 CD5 、 Clone (B-cell biology) 、 Interleukin 2 、 Immune system 、 Immunology 、 Biology 、 IL-2 receptor
摘要: B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by an accumulation of clonal malignant B cells. The intrinsic characteristics that permit this have been extensively studied and described. However, it possible proliferation survival clone facilitated a disruption in the interaction between T cells normally regulate immune system. In study, using flow cytometry cell culture techniques, marked abnormalities expression certain key activation molecules on peripheral blood patients with B-CLL were demonstrated. particular, comparison normal controls, there was reduction number circulating expressing CD25 (interleukin 2 receptor) (P = 0·007), CD28 (P = 0·01) CD152 (CTLA-4) (P = 0·001). There also CD4 (P = 0·03), CD5 (P = 0·05) CD11a (P = 0·01). no difference T-cell receptor αβ (P = 0·1), CD8 (P = 0·4), CD54 (P = 0·4) CD154 (P = 0·5), only marker expressed greater HLA-DR (P = 0·05). These results suggest profound dysregulation may contribute to related autoimmune phenomena disease.
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