Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.

摘要: Abstract Ethnopharmacological relevance Hyptis fruticosa is a plant native to Brazil with antinociceptive and antiinflamatory properties. This study evaluated the activity of hydroethanol extract leaves (CHEE) against orofacial pain as well its in vitro effect lipid peroxidation. Materials methods The was investigated mice orally treated different doses CHEE (50, 100, 200 mg/kg) morphine (5 mg/kg) using formalin, glutamate, capsaicin models using. Lipoperoxidation induced egg yolk by AAPH FeSO 4 absence presence (5, 50, 150 μg/mL). Results (200 mg/kg) significantly reduced ( ρ (82.3% TBARS inhibition) than (35.7% at 150 μg/mL. Conclusion leaf pharmacological interest because it able inhibit peripheral central transmission pain, while reducing spreading inflammatory processes neutralizing reactive oxygen species, which are by-products biosynthesis mediators.