TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting
作者： T. Hayase , S. Sugino , H. Moriya , M. Yamakage
DOI: 10.1111/ANAE.13082
关键词: Gastroenterology 、 Sex characteristics 、 Polymorphism (computer science) 、 Anesthesia 、 Incidence (epidemiology) 、 Single-nucleotide polymorphism 、 Internal medicine 、 Haplotype 、 Medicine 、 Genotype 、 Abdominal surgery 、 Postoperative nausea and vomiting
摘要: We hypothesised that the genetic effect of single nucleotide polymorphisms in TACR1 gene, which encodes NK1 receptors, could influence sex difference postoperative nausea and vomiting. Thirty-two selected were genotyped by Sanger sequencing method 200 patients who underwent lower abdominal surgery. The incidence severity vomiting evaluated after rs3755468-SNP showed significant association with (p = 0.016). TT haplotype defined two polymorphisms, including rs3755468-SNP, was associated reduced female (p = 0.03). is located within predicted oestrogen response element a DNase I hypersensitive site. gene are differences may help to elucidate mechanisms underlying these differences.
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sci-hub.se 参考文章(56)
Yao-Xia Wang, Wen-Hui Chen, Zhi-Hong Yang, Qiu-Hai Qian, Wang Yue, Zhan-Tao Liu, Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink Chinese Medical Journal. ,vol. 123, pp. 478- 484 ,(2010)
A.R Martin, A.D Carides, J.D Pearson, K Horgan, M Elmer, C Schmidt, B Cai, S.P Chawla, S.M Grunberg, Functional relevance of antiemetic control. Experience using the FLIE questionnaire in a randomised study of the NK-1 antagonist aprepitant. European Journal of Cancer. ,vol. 39, pp. 1395- 1401 ,(2003) , 10.1016/S0959-8049(03)00299-5
L Brooke Hayward, Jonathan Segal, Paul Van Eerdewegh, Kathryn L Lunetta, Screening large-scale association study data: exploiting interactions using random forests BMC Genetics. ,vol. 5, pp. 32- 32 ,(2004) , 10.1186/1471-2156-5-32
, A User's Guide to the Encyclopedia of DNA Elements (ENCODE) PLOS Biology. ,vol. 9, ,(2011) , 10.1371/JOURNAL.PBIO.1001046
Piotr K. Janicki, Shigekazu Sugino, Genetic factors associated with pharmacotherapy and background sensitivity to postoperative and chemotherapy-induced nausea and vomiting. Experimental Brain Research. ,vol. 232, pp. 2613- 2625 ,(2014) , 10.1007/S00221-014-3968-Z
Piotr K. Janicki, Ryan Vealey, Jiabin Liu, Jeremiah Escajeda, Marek Postula, Kelli Welker, Genome-wide Association Study Using Pooled DNA to Identify Candidate Markers Mediating Susceptibility to Postoperative Nausea and Vomiting Anesthesiology. ,vol. 115, pp. 54- 64 ,(2011) , 10.1097/ALN.0B013E31821810C7
Amartya Sanyal, Bryan R. Lajoie, Gaurav Jain, Job Dekker, The long-range interaction landscape of gene promoters Nature. ,vol. 489, pp. 109- 113 ,(2012) , 10.1038/NATURE11279
Paul J. Hesketh, Matti Aapro, James C. Street, Alexandra D. Carides, Evaluation of risk factors predictive of nausea and vomiting with current standard-of-care antiemetic treatment: analysis of two phase III trials of aprepitant in patients receiving cisplatin-based chemotherapy Supportive Care in Cancer. ,vol. 18, pp. 1171- 1177 ,(2010) , 10.1007/S00520-009-0737-9
Ross C. Hardison, James Taylor, Genomic approaches towards finding cis-regulatory modules in animals. Nature Reviews Genetics. ,vol. 13, pp. 469- 483 ,(2012) , 10.1038/NRG3242
Christian J Gruber, Doris M Gruber, Isabel M.L Gruber, Fritz Wieser, Johannes C Huber, Anatomy of the estrogen response element Trends in Endocrinology and Metabolism. ,vol. 15, pp. 73- 78 ,(2004) , 10.1016/J.TEM.2004.01.008