作者: Stefanie Klenke , Ulrich H. Frey
DOI: 10.1097/EJA.0000000000001224
关键词:
摘要: Background Postoperative nausea and vomiting (PONV) is the most frequent side effect following anaesthesia. Predisposition to developing PONV multifactorial with patient risk factors anaesthetic techniques both being contributory. However, there also a genetic susceptibility PONV, several studies have aimed identify polymorphisms contributing risk. Objective We summarised previous published investigating contribution Design Systematic review without meta-analysis. Data source searched MEDLINE until June 2019. Eligibility criteria Articles were chosen for when included. Exclusion reviews/meta-analysis/comments, articles not in English language, nonappropriate content (e.g. as primary aim of study, study investigated opioid-induced nausea) or if pharmacogenetic addressing treatment PONV. Results A total 59 screened 14 reviewed including one genome-wide association (GWAS). Seven performed East Asians, seven Caucasians. Seventeen been positively associated at least study. Allele frequency differs widely between ethnicities. Furthermore, anaesthesia regimen postoperative time point which was reported quite different. Only two polymorphisms, CHRM3 rs2165870 KCNB2 rs349358 (both first GWAS), significantly incidence Caucasians independent studies. Conclusion There development Two single nucleotide (SNPs), SNP, seem major influence on incidence, Both SNPs primarily identified GWAS this may lead better understanding disease aetiology. Further high-quality are needed reveal more insights susceptibility, particularly so non-Caucasian