Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.
作者： Natasha M. DeVore , Emily E. Scott
DOI: 10.1038/NATURE10743
关键词: Lyase 、 Cytochrome P450 、 CYP17A1 、 Chemistry 、 Prostate cancer 、 CYP17A1 Inhibitor 、 Lyase activity 、 Drug development 、 Drug design 、 Pharmacology
摘要: … models and from steroids in other cytochrome P450 enzymes with known structures, and … that will facilitate a better understanding of the enzyme’s dual hydroxylase and lyase catalytic …
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