Nanotherapy for posterior eye diseases

摘要: It is assumed that more than 50% of the most enfeebling ocular diseases have their origin in posterior segment. Furthermore, these lead to partial or complete blindness, if left untreated. After cancer, blindness second dreaded disease world over. However, treatment eye challenging anterior segment ailments due a series anatomical barriers and physiological constraints confronted for delivery this In regard, nanostructured drug systems are proposed defy barriers, target retina, act as permeation enhancers addition providing controlled release. Since an important step towards developing effective strategies understand course route molecule needs follow reach site, first part present review discusses various pathways available clearance from eye. Promise held by nanocarrier systems, viz. liposomes, nanoparticles, nanoemulsion, selective targeting also discussed with illustrative examples, tables, flowcharts. applicability self-administration drops still unrealized dream which itself huge technological challenge.