Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials

摘要: Background and aim: Fenugreek is a herb that widely used in cooking as traditional medicine for diabetes Asia. It has been shown to acutely lower postprandial glucose levels, but the long-term effect on glycemia remains uncertain. We systematically reviewed clinical trials of fenugreek intake markers homeostasis. Methods: PubMed, SCOPUS, Cochrane Trials Registry, Web Science, BIOSIS were searched up 29 Nov 2013 at least 1 week duration comparing seeds with control intervention. Data change fasting blood glucose, 2 hour postload HbA1c pooled using random-effects models. Results: A total 10 identified. significantly changed by -0.96 mmol/l (95% CI: -1.52, -0.40; I =80%; trials), -2.19 -3.19, -1.19; =71%; 7t rials) -0.85% -1.49%, -0.22%; =0%; 3 trials) compared interventions. The considerable heterogeneity study results was partly explained status dose: significant effects hr only found studies administered medium or high doses persons diabetes. Most low methodological quality.