The postprandial hypoglycemic activity of fenugreek seed and seeds' extract in type 2 diabetics: a pilot study.

作者: Sofyan N Maghaydah , Hiba A Bawadi , Rabab F Tayyem , Reema F Tayyem

DOI:

关键词:

摘要: Trigonella foenum-groecum L. is directly related to the traditional use. foenum-graecum L, have been reported be beneficial for treating type 2 diabetes (T2D). The study was conducted investigate postprandial hypoglycemic effect of fenugreek seeds on patients with T2D. Pretest - posttest control group design used test hypothesis that may a blood sugar. One hundred sixty-­six D2T were assigned into three groups: FGO (control group: placebo drink), FG2.5 (2.5g fenugreek), and FG5 (5g fenugreek). Participants instructed drink extract chew seeds. Postprandial plasma glucose level measured before 2-hours after administration treatment. Accounting gender, age, education, physical activity, body mass index, glycemic control, medication, in showed greatest decrease pretest-posttest difference (D) 41 ± 6.1 mg/dl. Two-hour dropped FG2.5, however, drop not statistically different from noticed (D = 24.8 4.9 mg/dl vs. 9.8 2.2 respectively). Fenugreek appear significant activity T2D patients.

参考文章(25)
P S Murthy, D Puri, K M Prabhu, Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian journal of physiology and pharmacology. ,vol. 46, pp. 457- 462 ,(2002)
P Sowmya, P Rajyalakshmi, None, Hypocholesterolemic effect of germinated fenugreek seeds in human subjects Plant Foods for Human Nutrition. ,vol. 53, pp. 359- 365 ,(1999) , 10.1023/A:1008021618733
Zhi-Lun Wang, Yong-Hui Liu, Xuan-She Li, Rui-Juan Zhang, Wan-Li Xue, Jian Zhang, Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pacific Journal of Clinical Nutrition. ,vol. 16, pp. 422- 426 ,(2007) , 10.6133/APJCN.2007.16.S1.77
A AMIN, A ALKAABI, S ALFALASI, S DAOUD, Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer Cell Biology International. ,vol. 29, pp. 687- 694 ,(2005) , 10.1016/J.CELLBI.2005.04.004
Abha Saxena, Naval Kishore Vikram, None, Role of selected Indian plants in management of type 2 diabetes: a review. Journal of Alternative and Complementary Medicine. ,vol. 10, pp. 369- 378 ,(2004) , 10.1089/107555304323062365
Tayyaba Zia, S.Nazrul Hasnain, S.K Hasan, Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. Journal of Ethnopharmacology. ,vol. 75, pp. 191- 195 ,(2001) , 10.1016/S0378-8741(01)00186-6
Mohamed Z. Gad, Maha M. El-Sawalhi, Manal F. Ismail, Nibal D. El-Tanbouly, Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites Molecular and Cellular Biochemistry. ,vol. 281, pp. 173- 183 ,(2006) , 10.1007/S11010-006-0996-4
Maleppillil Vavachan Vijayakumar, Sandeep Singh, Rishi Raj Chhipa, Manoj Kumar Bhat, The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. British Journal of Pharmacology. ,vol. 146, pp. 41- 48 ,(2005) , 10.1038/SJ.BJP.0706312
Philip Clarke, Jose Leal, Chris Kelman, Merran Smith, Stephen Colagiuri, Estimating the Cost of Complications of Diabetes in Australia Using Administrative Health-Care Data Value in Health. ,vol. 11, pp. 199- 206 ,(2008) , 10.1111/J.1524-4733.2007.00228.X
J Mishkinsky, B Joseph, F.G Sulman, AL Goldschmied, HYPOGLYCÆMIC EFFECT OF TRIGONELLINE The Lancet. ,vol. 290, pp. 1311- 1312 ,(1967) , 10.1016/S0140-6736(67)90428-X