Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

摘要: The present review focuses on the mouse as an experimental immunopathologic model for human non-Hodgkin's lymphomas and related leukemias. Immunomorphologic evidence is presented that clearly demonstrates B- T-cell subtypes of (murine) lymphoma/leukemia closely resemble are analogous to defined by recently proposed immunomorphologic classifications. Further favors hypothesis certain types murine B-cell lymphoma develop out prodromal, prelymphomatous states, which exhibit antecedent morphologic immunologic abnormalities. many advantages systems stressed, well concept presently approach should be effectively combined with molecular cytogenetic parameters.