Cerebral circulation and oxygen metabolism in Moyamoya disease of ischemic type in children

摘要: Cerebral rCBF, rOEF, rCMRO2, and rCBV in moyamoya disease were studied by means of positron emmission tomography (PET), using 15O as a tracer. Steady-state methods with C15O2 15O2 used to obtain the functional images rOEF. The single-inhalation method was image. Five children (two boys three girls) mean age 11 years eight normal volunteers 31 included study. symptoms due cerebral ischemia, such transient ischemic attack (TIA), reversible neurological deficit (RIND), minor stroke. interval between latest ictus PET scan ranged from 3 days 6 months. Physiological parameters (rCBF, rCMRO2 etc.) gray matter, white matter basal ganglia calculated single images. Any, low density areas appearing X-ray-CT performed just prior study carefully excluded analysis. statistically compared control parameters. Though value rCBF slightly higher disease, this difference not significant. On other hand, increased significantly ganglia. ratio CBF CBV is considered be index perfusion pressure reciprocal transit time under autoregulation CBF. This for each tissue. decreased tissue indicating presence brain. In general, when reduction becomes profound decrease CBF-to-CBV followed an increase spite there no significant rOEF disease. Thus, circulation childhood type characterized mild prolonged time.