Determinants for Neoantigen Identification.

摘要: All tumors accumulate genetic alterations, some of which can give rise to mutated, non-self peptides presented by human leukocyte antigen (HLA) molecules and elicit T-cell responses. These immunogenic mutated peptides, or neoantigens, are foreign in nature display exquisite tumor specificity. The correlative evidence suggesting they play an important role the effectiveness various cancer immunotherapies has triggered development vaccines adoptive therapies targeting them. However, systematic identification personalized neoantigens patients, a critical requisite for success these therapies, remains challenging. A growing amount supports that only small fraction all somatic non-synonymous mutations (NSM) identified represent bona fide neoantigens; processed, on cell surface HLA cells capable triggering immune responses patients. Here, we provide overview existing strategies identify candidate evaluate their immunogenicity, two factors impact neoantigen identification. We will focus strengths limitations allow readers rationally select apply most suitable method specific laboratory setting.