T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.
作者： Alok V. Joglekar , Michael T. Leonard , John D. Jeppson , Margaret Swift , Guideng Li
DOI: 10.1038/S41592-018-0304-8
关键词:
摘要: CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress characterizing the antitumor cell repertoire function, identification of target antigens remains a challenge. Here we describe use chimeric receptors called signaling antigen-presenting bifunctional (SABRs) cell-based platform for receptor (TCR) antigen discovery. SABRs present extracellular complex comprising peptide major histocompatibility (MHC), induce intracellular via TCR-like signal after binding with cognate TCR. We devised strategy discovery using SABR libraries to screen thousands antigenic epitopes. validated this by identifying targets recognized public TCRs known specificities. Moreover, extended approach personalized neoantigen
nature.com
sci-hub.se 参考文章(34)
Vijay Shankaran, Hiroaki Ikeda, Allen T. Bruce, J. Michael White, Paul E. Swanson, Lloyd J. Old, Robert D. Schreiber, IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity Nature. ,vol. 410, pp. 1107- 1111 ,(2001) , 10.1038/35074122
Yik Y. L. Yu, Nikolai Netuschil, Lonnie Lybarger, Janet M. Connolly, Ted H. Hansen, Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells. Journal of Immunology. ,vol. 168, pp. 3145- 3149 ,(2002) , 10.4049/JIMMUNOL.168.7.3145
Daniel J Woodsworth, Mauro Castellarin, Robert A Holt, Sequence analysis of T-cell repertoires in health and disease Genome Medicine. ,vol. 5, pp. 98- 98 ,(2013) , 10.1186/GM502
Paul Klenerman, Vincenzo Cerundolo, P. Rod Dunbar, Tracking T cells with tetramers: new tales from new tools Nature Reviews Immunology. ,vol. 2, pp. 263- 272 ,(2002) , 10.1038/NRI777
Michael E. Birnbaum, Juan L. Mendoza, Dhruv K. Sethi, Shen Dong, Jacob Glanville, Jessica Dobbins, Engin Özkan, Mark M. Davis, Kai W. Wucherpfennig, K. Christopher Garcia, Deconstructing the Peptide-MHC Specificity of T Cell Recognition Cell. ,vol. 157, pp. 1073- 1087 ,(2014) , 10.1016/J.CELL.2014.03.047
Michael S Bennett, Aviva Joseph, Hwee L Ng, Harris Goldstein, Otto O Yang, Fine Tuning of T Cell Receptor Avidity to Increase HIV Epitope Variant Recognition by Cytotoxic T Lymphocytes AIDS. ,vol. 24, pp. 2619- 2628 ,(2010) , 10.1097/QAD.0B013E32833F7B22
Pier-Luigi Lollini, Federica Cavallo, Patrizia Nanni, Guido Forni, Vaccines for tumour prevention Nature Reviews Cancer. ,vol. 6, pp. 204- 216 ,(2006) , 10.1038/NRC1815
C. Yee, J. A. Thompson, D. Byrd, S. R. Riddell, P. Roche, E. Celis, P. D. Greenberg, Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 16168- 16173 ,(2002) , 10.1073/PNAS.242600099
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis, Lieping Chen, Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion Nature Medicine. ,vol. 8, pp. 793- 800 ,(2002) , 10.1038/NM730
Eric Tran, Simon Turcotte, Alena Gros, Paul F Robbins, Yong-Chen Lu, Mark E Dudley, John R Wunderlich, Robert P Somerville, Katherine Hogan, Christian S Hinrichs, Maria R Parkhurst, James C Yang, Steven A Rosenberg, Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science. ,vol. 344, pp. 641- 645 ,(2014) , 10.1126/SCIENCE.1251102