Molecular size of retinal vascular leakage determined by FITC-dextran angiography in patients with posterior uveitis.
作者： E G Atkinson , S Jones , B A Ellis , D C Dumonde , E Graham
DOI: 10.1038/EYE.1991.71
关键词: Dextran 、 Blood–retinal barrier 、 Surgery 、 Retinal 、 Angiography 、 Fluorescein angiography 、 Uveitis 、 Ophthalmology 、 Eye disease 、 Uvea 、 Medicine
摘要: In order to investigate the selective breakdown of blood-retinal barrier in posterior uveitis angiograms were performed using fluorescein-conjugated dextrans (FITC-dextrans) different molecular weights (150-kDa, 20-kDa, and 4-kDa) two healthy controls six patients with uveitis, results compared those conventional fluorescein angiography. The smallest FITC-dextran could not penetrate barrier. Leakage FITC-dextrans all sizes was seen from swollen optic discs; 4-kDa 20-kDa leaked areas macula oedema; retinal new vessels allowed passage molecules only. These indicate that there is a differential according size various clinical situations associated uveitis.
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