CXCL12/CXCR4 promotes motility and proliferation of glioma cells.
作者： Anália do Carmo , I. Patricio , M.T. Cruz , H. Carvalheiro , C.R. Oliveira
关键词: Apoptosis 、 Chemokine receptor 、 Motility 、 Glioma 、 Cell culture 、 Cell growth 、 Hedgehog signaling pathway 、 Biology 、 Cell biology 、 CXCR4 、 Cancer research
摘要: Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, CXCL12/SDF-1 chemokine receptor. To better understand role CXCR4 in GBM biology we performed an integrated study where simultaneously evaluate contribution CXCR4/CXCL12 signaling pathway to proliferation, survival motility a human cell line. Our results axis induced increase proliferation motility. The blockage significant apoptosis. Together, our signalling may contribute development emphasize therapeutic potential this patients with GBM.
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