CXCR4 expression mediates glioma cell invasiveness.

摘要: Glioblastoma multiforme is a highly invasive tumor bearing dismal prognosis. Experimental strategies that focus on the specific biological cues governing capacity of these tumors may hold significant therapeutic promise. In this context, we describe in vitro and vivo association cell surface chemokine receptor, CXCR4, with development an phenotype malignant glioblastoma. We demonstrate populations glioma cells overexpress CXCR4 at message protein levels, expression ranges from 25- to 89-fold higher than found noninvasive cells. Furthermore, neutralization significantly impairs glial addition, secrete CXCL12 robust toward gradient vitro. These findings underscore importance as potential target for treatment