Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin.

摘要: Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content has important implications understanding plasticity and neurodegenerative diseases. water imaging a magnetic resonance method which can be used to visualize myelination the spinal cord vivo. This review presents an overview data acquisition analysis, post-mortem validation work, findings both animal human studies brief discussion about other MR techniques purported provide content. Multi-echo T2 relaxation approaches continue undergo development whole-brain time now takes less than 10 minutes; standard analysis this type non-negative least squares approach. Alternate methods including multi-flip angle gradient echo mcDESPOT are also being imaging. Histological tissue demonstrate high specificity myelin. Potential confounding factors fraction measurement include presence debris magnetization exchange processes. successfully been study models injury, applied controls assess damage injury conditions such as multiple sclerosis, neuromyelitis optica, schizophrenia, phenylketonuria, neurofibromatosis, niemann pick's disease, stroke concussion. Other quantitative that sensitive to, but not specific for, exist transfer, diffusion tensor T1 weighted