Frequency of Familial Gastric Cancer
作者： Giovanni Corso , Daniele Marrelli
DOI: 10.1007/978-94-007-6570-2_2
关键词: Gastric tumor 、 Family history 、 Internal medicine 、 Germline mutation 、 CDH1 、 Cancer 、 Medicine 、 Oncology 、 Incidence (epidemiology) 、 Proband 、 Geographic variation
摘要: About 80–90 % of gastric cancer appears as sporadic form, and 10–20 with a familial setting; however, considering the different worldwide countries, this frequency extremely variable. In high risk-area for tumors incidence results higher than in low-risk zones. Conversely, CDH1 germline mutations is contrasting carcinoma. Exploring these considerations, high-risk area it seems that environmental factors exercise stronger mechanism carcinogenesis. This data could open new approaches prevention test; before to candidate proband genetic screening, geographic variability, alongside family history should be considered.
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