Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo.

作者: Rashmi Rajappa , Dornadula Sireesh , Magesh B. Salai , Kunka M. Ramkumar , Suryanarayanan Sarvajayakesavulu

DOI: 10.3389/FPHAR.2018.01562

关键词: Oxidative stressApoptosisPancreasActivator (genetics)ChemistryInsulinGlycolysisNaringeninStreptozotocinPharmacology

摘要: Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related factor 2 (Nrf2) controls the expression of …

参考文章(77)
Angélica Saraí Jiménez-Osorio, Susana González-Reyes, José Pedraza-Chaverri, Natural Nrf2 activators in diabetes Clinica Chimica Acta. ,vol. 448, pp. 182- 192 ,(2015) , 10.1016/J.CCA.2015.07.009
Sarah E. Lacher, Joslynn S. Lee, Xuting Wang, Michelle R. Campbell, Douglas A. Bell, Matthew Slattery, Beyond antioxidant genes in the ancient Nrf2 regulatory network Free Radical Biology and Medicine. ,vol. 88, pp. 452- 465 ,(2015) , 10.1016/J.FREERADBIOMED.2015.06.044
Xuan XIA, Jianping WENG, Targeting metabolic syndrome: candidate natural agents Journal of Diabetes. ,vol. 2, pp. 243- 249 ,(2010) , 10.1111/J.1753-0407.2010.00090.X
Ozra Tabatabaei-Malazy, Bagher Larijani, Mohammad Abdollahi, Targeting metabolic disorders by natural products Journal of Diabetes & Metabolic Disorders. ,vol. 14, pp. 57- 57 ,(2015) , 10.1186/S40200-015-0184-8
William H. Habig, Michael J. Pabst, William B. Jakoby, Glutathione S-Transferases Journal of Biological Chemistry. ,vol. 249, pp. 7130- 7139 ,(1974) , 10.1016/S0021-9258(19)42083-8
P N Viswanathan, Poonam Kakkar, Ballabh Das, A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics. ,vol. 21, pp. 130- 132 ,(1984)
P Bhuvaneswari, P Rajeswari, S Krishnakumari, Ameliorative potential of Coccinia grandis extract on serum and liver marker enzymes and lipid profile in streptozotocin induced diabetic rats. Ancient Science of Life. ,vol. 31, pp. 26- 30 ,(2011)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Anthony E. Pegg, Richard A. Bennett, Alkylation of DNA in Rat Tissues following Administration of Streptozotocin Cancer Research. ,vol. 41, pp. 2786- 2790 ,(1981)