Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat

摘要: Hemoglobin-based oxygen carriers (HBOC) have been primarily studied for blood loss treatment. More recently infusions of HBOC in euvolemic subjects proposed a wide variety potential therapies which increased tissue oxygenation would be beneficial. However, compared with the exchange transfusion models to study loss, less is known about delivery and vasoacitvity when it infused subjects. We hypothesized that [polymerized bovine hemoglobin (PBvHb)] infusion creating hypervolemia increase tissues during acute global hypoxia. Vascular content hemodynamics were determined after rats 3 ml either lactated Ringer or PBvHb solution (13 g/dl, 1.3 g/kg) hypoxia (FIO2 = 10%, 4 h) normoxia 21%) exposure. Our data demonstrated Ringer-infused animals, normoxia, treatment improved but raised mean arterial pressure, lowered stroke volume, heart rate, cardiac index, resulted net reduction flow tissues. The vasoactive effect was similar magnitude direction as animals treated nitric oxide synthase inhibitor nitro-l-arginine, suggesting mediated via scavenging. conclude not likely useful treating under these conditions.