A method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition

摘要: A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury vasoconstriction is provided. high temperature short time (HTST) processing step performed to remove undesired dimeric form of hemoglobin, uncross-linked plasma protein impurities effectively. Addition N-acetyl cysteine after treatment optionally before maintains a low level met-hemoglobin. The can improve prolong oxygenation normal hypoxic tissue. In another aspect, the product used various types cancer such as leukemia, colorectal cancer, lung breast liver nasopharyngeal carcinoma esophageal cancer. Another application heart preservation situations where there lack oxygen supply vivo, transplant or oxygen-deprived heart.