PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model

摘要: Liver plays a major role in hypermetabolism and produces acute phase proteins during systemic inflammatory response syndrome it is of vital importance host defense bacteria clearance. Our previous studies indicated that programmed death-1 (PD-1) its ligand death ligand-1 (PD-L1) are crucial modulators immune responses sepsis. current study was designed to investigate the PD-L1 sepsis-induced liver injury by mouse cecal ligation puncture (CLP) model. results there significant increase expression after CLP challenge compared sham-operated controls, terms levels mRNA transcription immunohistochemistry. Anti-PD-L1 antibody significantly alleviated morphology mice. administration decreased ALT AST release mice, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10 sepsis challenge. Thus, anti-PD-L1 might have therapeutic potential attenuating