Trichoblastic sarcoma: a high-grade stromal tumor arising in trichoblastoma.

摘要: We report a case of primary sarcoma the skin with biphasic histological pattern, being composed areas mixed mesenchymal-epithelial cell proliferation and purely sarcomatous growth. The tumor occurred in posterior cervical region 93-year-old man, its history was marked by sudden, rapid enlargement after many years stable duration. excised lesion about 4 cm diameter, had firm consistency covered intact skin. Histological examination showed multifocal follicular germinative cells arranged corymbiform petaloid shapes an overall retiform growth pattern. Epithelial cords strands were cytologically uniform bland nuclear features surrounded prominent, fibroblast-rich stroma reminiscent perifollicular sheath. In abrupt transition into pleomorphic large frequent often atypical mitoses. Multinucleated neoplastic infiltrated epithelial structures to cause their partial or total obliteration fields lesion. Immunohistochemically, displayed expression various keratins, particularly intense staining for 34betaE12, partly positive CD10 antigen. A strong immunostaining this antigen also observed malignant-appearing stromal areas, where no cytokeratins detected. Moreover, positivity p53 protein seen cells, whereas it resulted lack elements. Our emphasizes that high-grade may occur spectrum trichoblastic tumors share some other noncutaneous neoplasms, such as mammary cystosarcoma phyllodes.