Stromal CD10 expression in mammary fibroadenomas and phyllodes tumours

摘要: Background/Aims: CD10 (CALLA) has recently been reported to be expressed in spindle cell neoplasia, and used differentiate endometrial stromal sarcoma from leiomyoma leiomyosarcoma. In the breast, myoepithelial cells express CD10, but there are few studies of expression mammary fibroepithelial lesions. Methods: Stromal was studied 181 phyllodes tumours (102 benign, 51 borderline malignant, 28 frankly malignant) 33 fibroadenomas using immunohistochemistry, evaluate whether differences correlated with degree malignancy. Results: There a progressive increase patients’ age tumour size, fibroadenoma an increasing malignancy (p < 0.001). positive one fibroadenomas, six 102 benign tumours, 16 malignant 14 tumours. The difference significant 0.001) trend established. Strong staining seen subepithelial areas higher cellularity activity. had high specificity (95%) for differentiating between lesions (fibroadenomas tumours) (borderline tumours. Conclusions: may useful adjunct assessing lesions.