T-helper phenotype chronic lymphocytic leukemia (Thp-CLL): Characterization of an Italian case with particular biological findings
作者： D. Pasqualetti , A. Cafaro , R. Gastaldi , M. Lopez , F. Malagnino
DOI: 10.1007/BF00320877
关键词: Phenotype 、 Lymphocyte 、 Immunology 、 Internal medicine 、 Retrovirus 、 Chronic lymphocytic leukemia 、 Virus 、 Hematology 、 Biology 、 B cell 、 Cytogenetics
摘要: A patient with Chronic Lymphocytic Leukemia (CLL) characterized by an expansion of helper phenotype mature T lymphocytes is here described. The these cells was OKT3+, OKT4+, Leu 9+, 5/9+, OKT8−, Tac− and functional studies showed a strong activity on B cell differentiation; “in vivo” presence IgG-lambda paraproteinaemia has been demonstrated. Cytogenetic multiple clonal, numerical structural rearrangements which included tandem t (14; 14) (q11; 32) translocation. Hybridization HTLV I related specific bands indicating the exogenous sequences to prototype virus but derived from different Retrovirus (HTLV 1c). clinical course aggressive unsuccessful treatments various polichemotherapeutic protocols, associated leukaphereses, were performed. authors underline that despite morphological, immunological, biological virological heterogeneity, common feature T-helper CLL inexorable needs new therapeutic approach.
springer.com
sci-hub.se 参考文章(31)
Marjorie Robert-Guroff, Philip D. Markham, Mikulas Popovic, Robert C. Gallo, Isolation, characterization, and biological effects of the first human retroviruses: the human T-lymphotropic retrovirus family. Current Topics in Microbiology and Immunology. ,vol. 115, pp. 7- 31 ,(1985) , 10.1007/978-3-642-70113-9_2
Y Ueshima, JD Rowley, D Variakojis, J Winter, L Gordon, Cytogenetic studies on patients with chronic T cell leukemia/lymphoma Blood. ,vol. 63, pp. 1028- 1038 ,(1984) , 10.1182/BLOOD.V63.5.1028.1028
KR Rai, A Sawitsky, EP Cronkite, AD Chanana, RN Levy, BS Pasternack, Clinical staging of chronic lymphocytic leukemia. Blood. ,vol. 46, pp. 219- 234 ,(1975) , 10.1182/BLOOD.V46.2.219.219
Robert J. Biggar, James J. Goedert, William A. Blattner, Jeffrey W. Clark, Stanley H. Weiss, Epidemiology of human lymphotrophic retroviruses: an overview. Cancer Research. ,vol. 45, ,(1985)
F Pandolfi, G De Rossi, G Semenzato, I Quinti, A Ranucci, G De Sanctis, M Lopez, G Gasparotto, F Aiuti, Immunologic evaluation of T chronic lymphocyte leukemia cells: correlations among phenotype, functional activities, and morphology. Blood. ,vol. 59, pp. 688- 695 ,(1982) , 10.1182/BLOOD.V59.4.688.688
F Pandolfi, G De Rossi, A Ranucci, G Bonomo, D Pasqualetti, M Napolitano, V Manzari, Tac-positive, HTLV-negative, T helper phenotype chronic lymphocytic leukemia cells. Blood. ,vol. 65, pp. 1531- 1537 ,(1985) , 10.1182/BLOOD.V65.6.1531.BLOODJOURNAL6561531
Franco Pandolfi, GiulioDe Rossi, Francesco Lauria, Alessandra Ranucci, Giovanni Barillari, Vittorio Manzari, Gianpietro Semenzato, Vincenzo Liso, Giovanni Pizzolo, Fernando Aiuti, T-HELPER PHENOTYPE CHRONIC LYMPHOCYTIC LEUKAEMIA AND "ADULT T-CELL LEUKAEMIA" IN ITALY: Endemic HTLV-I-related T-cell Leukaemias in Southern Europe The Lancet. ,vol. 326, pp. 633- 636 ,(1985) , 10.1016/S0140-6736(85)90004-2
T Hattori, T Uchiyama, T Toibana, K Takatsuki, H Uchino, Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies Blood. ,vol. 58, pp. 645- 647 ,(1981) , 10.1182/BLOOD.V58.3.645.BLOODJOURNAL583645
Franco Pandolfi, Franco Mandelli, Gianpietro Semenzato, Alessandra Ranucci, Fernando Aiuti, Classification of patients with T-cell chronic lymphocytic leukemia and expansions of granular lymphocytes: heterogeneity of Italian cases by a multiparameter analysis. Journal of Clinical Immunology. ,vol. 4, pp. 174- 184 ,(1984) , 10.1007/BF00914964
Kanji Miyamoto, Jiro Sato, Ko-Ichi Kitajima, Atushi Togawa, Shuso Suemaru, Hiroshi Sanada, Toshio Tanaka, Adult T-cell leukemia. Chromosome analysis of 15 cases Cancer. ,vol. 52, pp. 471- 478 ,(1983) , 10.1002/1097-0142(19830801)52:3<471::AID-CNCR2820520316>3.0.CO;2-E