Type I insulin-like growth factor receptor induces pulmonary tumorigenesis.

摘要: Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model IGF-IR overexpression has not been created. We produced two novel mouse models which is overexpressed either II alveolar cells (surfactant protein C [SPC]-IGFIR) or Clara (CCSP-IGFIR) doxycycline-inducible manner. Overexpression cell caused multifocal adenomatous hyperplasia with papillary and solid adenomas. These tumors thyroid transcription 1 Kruppel-like 5 most tumor cells. Similar to our previous work that developed mammary virus-IGF-II mice, develop SPC-IGFIR CCSP-IGFIR mice high levels cyclic adenosine monophosphate response element binding was localized primarily nucleus. Although elevated expression can initiate development, become independent signaling as down-regulation established regression some, but all, tumors. findings implicate an important initiator tumorigenesis suggest be used further understanding cancer role plays this disease.