Parathyrin and calcitonin stimulate cyclic AMP accumulation in cultured murine brain cells.

摘要: Despite the key role Ca2+ plays in nervous system, biochemical actions on neural tissue of Ca2+-regulating peptide hormones parathyrin and calcitonin were unknown. Until a few years ago only neurons, but not glial cells, considered as targets for hormones. Our recent observation that do indeed act cells is extended by present report these respond to calcaemic calcitonin. In cultured murine brain mainly consisting glioblasts, stimulates accumulation cyclic AMP. The half-maximal effect elicited at 30 nM parathyrin. With rat effects are three times those observed with mouse cells. Calcitonin, which less potent than parathyrin, elevates concentration AMP If properly occupied, inhibitory receptors lower increase level evoked and, some extent, results suggest that: (i) or closely related might exert regulatory functions brain; (ii) must be discussions other