Comparison of a calcitonin gene-related peptide receptor in a human neuroblastoma cell line (SK-N-MC) and a calcitonin receptor in a human breast carcinoma cell line (T47D).
作者： ROMAN MUFF , DANIEL STANGL , WALTER BORN , JAN A. FISCHER
DOI: 10.1111/J.1749-6632.1992.TB22760.X
关键词:
摘要: A specific CGRP-binding protein of M(r) 60,000 has been identified in the human neuroblastoma cell line SK-N-MC. After N-deglycosylation a 48,000 was found. The were indistinguishable from those determined cerebellum. Receptor binding CGRP is coupled to cyclic AMP formation. latter antagonized by hCGRP-I8-37. CT and DAPamide interact only minimally with receptor, whereas are full agonists T47D cells. receptor on breast cancer clearly different receptor.
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