The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats.
作者： Keith R. Laderoute , Siqing Shan , A. Craig Lockhart , Mark W. Dewhirst , Wilfred Y. Saito
DOI:
关键词: Cell growth 、 Growth factor 、 Mammary gland 、 Carcinoma 、 Angiogenesis 、 Neovascularization 、 Biology 、 Cornea 、 Pathology 、 Tubulin binding
摘要: … Because tubulin-binding drugs can have antiangiogenic activity, we hypothesized that BTO-956 could also inhibit angiogenesis. Here we present findings showing that BTO-956 has …
aacrjournals.org
elsevier.com参考文章(24)
Corazon D. Bucana, Corazon D. Bucana, Yasuhiko Kitadai, Yasuhiko Kitadai, Michael R. Wilson, Michael R. Wilson, Lee M. Ellis, Isaiah J. Fidler, Yutaka Takahashi, Yutaka Takahashi, Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice. Oncology Research. ,vol. 8, pp. 163- 169 ,(1996)
Dai Fukumura, Fan Yuan, Rakesh K. Jain, Wayne L. Monsky, Yi Chen, Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. American Journal of Pathology. ,vol. 151, pp. 679- 688 ,(1997)
Zishan A. Haroon, Joann M. Hettasch, Thung‐Shenq Lai, Mark W. Dewhirst, Charles S. Greenberg, Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis The FASEB Journal. ,vol. 13, pp. 1787- 1795 ,(1999) , 10.1096/FASEBJ.13.13.1787
Vivien E. Prise, George R. Pettit, Graham G. Dark, Sally A. Hill, Dai J. Chaplin, Gillian M. Tozer, Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature Cancer Research. ,vol. 57, pp. 1829- 1834 ,(1997)
Jerald J. Killion, Graham Greene, Michael R. Wilson, Edilberto Ramirez, Sen Pathak, Isaiah J. Fidler, Curtis A. Pettaway, Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clinical Cancer Research. ,vol. 2, pp. 1627- 1636 ,(1996)
Domenico Ribatti, Mirella Belleri, Lucia Morbidelli, Marco Presta, Marco Rusnati, Marina Ziche, Purine Analogue 6-Methylmercaptopurine Riboside Inhibits Early and Late Phases of the Angiogenesis Process Cancer Research. ,vol. 59, pp. 2417- 2424 ,(1999)
Sudha Iyer, Dai J Chaplin, Dean S Rosenthal, A Hamid Boulares, L Y Li, Mark E Smulson, Induction of Apoptosis in Proliferating Human Endothelial Cells by the Tumor-specific Antiangiogenesis Agent Combretastatin A-4 Cancer Research. ,vol. 58, pp. 4510- 4514 ,(1998)
Wadih Arap, Renata Pasqualini, Erkki Ruoslahti, Chemotherapy targeted to tumor vasculature Current Opinion in Oncology. ,vol. 10, pp. 560- 565 ,(1998) , 10.1097/00001622-199811000-00014
Heinz D. Papenfuss, Joseph F. Gross, Marcos Intaglietta, Fred A. Treese, A transparent access chamber for the rat dorsal skin fold. Microvascular Research. ,vol. 18, pp. 311- 318 ,(1979) , 10.1016/0026-2862(79)90039-6
Xiaoying Chen, Polly Pine, A.Merrill Knapp, Daniel Tusé, Keith R. Laderoute, Oncocidin A1: a novel tubulin-binding drug with antitumor activity against human breast and ovarian carcinoma xenografts in nude mice. Biochemical Pharmacology. ,vol. 56, pp. 623- 633 ,(1998) , 10.1016/S0006-2952(98)00210-X