作者: Daniela D. Schlereth
DOI: 10.1016/S0166-526X(05)44001-5
关键词: Context (language use) 、 Surface plasmon resonance 、 Ligand (biochemistry) 、 Nanotechnology 、 Silicon chip 、 Biomolecule 、 Microfabrication 、 Chemistry 、 Biosensor 、 Self-assembled monolayer
摘要: Publisher Summary This chapter focuses on the relevance of surface chemistry based self-assembling techniques within context manufacture analytical biosensing devices. The combination self-assembly and microfabrication techniques—such as photopatterning or microcontact printing—allows micrometer-scale arrays biomolecules distributed throughout a protein-resistant (e.g., surface-modified silicon chip), which are basis for high-throughput screening diagnostics Biological affinity system that is particularly useful construction biosensors biotin–streptavidin complex. Surface plasmon resonance- quartz microbalance-based have been widely used study binding interactions between receptor proteins, antibodies, nucleic acids their biological partners, wherein sensitivity, selectivity, reliability, time-response depend capability ligand immobilized sensor to build selectively reversibly