Chapter 1 Biosensors based on self-assembled monolayers

作者: Daniela D. Schlereth

DOI: 10.1016/S0166-526X(05)44001-5

关键词: Context (language use)Surface plasmon resonanceLigand (biochemistry)NanotechnologySilicon chipBiomoleculeMicrofabricationChemistryBiosensorSelf-assembled monolayer

摘要: Publisher Summary This chapter focuses on the relevance of surface chemistry based self-assembling techniques within context manufacture analytical biosensing devices. The combination self-assembly and microfabrication techniques—such as photopatterning or microcontact printing—allows micrometer-scale arrays biomolecules distributed throughout a protein-resistant (e.g., surface-modified silicon chip), which are basis for high-throughput screening diagnostics Biological affinity system that is particularly useful construction biosensors biotin–streptavidin complex. Surface plasmon resonance- quartz microbalance-based have been widely used study binding interactions between receptor proteins, antibodies, nucleic acids their biological partners, wherein sensitivity, selectivity, reliability, time-response depend capability ligand immobilized sensor to build selectively reversibly

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