Nonsteroidal antiinflammatory drugs could reverse Helicobacter pylori- induced apoptosis and proliferation in gastric epithelial cells

摘要: It remains controversial whether the harmful effects of Helicobacter pylori (Hp) and nonsteroidal antiinflammatory drugs (NSAIDs) are additive. We studied Hp (virulent nonvirulent strains) NSAIDs, alone or in combination, on apoptosis proliferation gastric epithelial cells nonulcer dyspepsia (NUD) patients. Forty-four (25 Hp-positive 19 Hp-negative) consecutive Chinese NUD patients with rheumatoid arthritis who had taken continuously NSAIDs for more than three months were recruited this study. Another 41 (20 21 not any included as controls. All underwent a gastroscopy examination biopsies. infection was confirmed by CLOtest, anti-Hp ELISA, [13C]urea breath test. The CagA status determined anti-CagA antibody assay. degree gastritis, apoptosis, indices H&E staining, terminal uridine deoxynucleotidyl nick end-labeling (TUNEL), proliferating cell nuclear antigen (PCNA) immunostaining methods, respectively. A significantly higher observed subjects been consuming when compared Unlike NSAID-treated subjects, shown to have enhanced proliferation. However, increased reversed also taking NSAIDs. No correlation found between all study groups. There no association expression gastritis apoptosis. demonstrated at cellular level that could abrogate induced Hp. Furthermore, latter appeared be influenced virulent nature strains.