Evolution of secretin family GPCR members in the metazoa
作者： João CR Cardoso , Vanda C Pinto , Florbela A Vieira , Melody S Clark , Deborah M Power
关键词: Secretin family 、 Protostome 、 G protein-coupled receptor 、 Evolutionary biology 、 Phylogenetics 、 Takifugu 、 Deuterostome 、 In silico 、 Genetics 、 Gene duplication 、 Biology
摘要: Background Comparative approaches using protostome and deuterostome data have greatly contributed to understanding gene function organismal complexity. The family 2 G-protein coupled receptors (GPCRs) are one of the largest best studied hormone neuropeptide receptor families. They suggested arisen from a single ancestral via duplication events. Despite recent identification members in early genomes, relatively little is known about their or origin during metazoan divergence. In this study comprehensive description GPCR evolution given based on silico expression analyses invertebrate genes.
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