A brief review on the evolution of GPCR: conservation and diversification

摘要: G-protein couple receptors (GPCR) possess diversified functions and they comprise a large protein superfamily in cellular signaling. Numerous identification methods for GPCR have been employed versatile types are discussed. Although share conserved transmembrane structural topology, alignment results of all show no significant sequence similarities. Each type distributes diversely different evolutionary hierarchies eukaryotes, but it has distinctive boundary the era metazoan. The common ancestor metabotropic glutamate receptor includes 7-transmembrane structure venus flytrap module, which is probably evolved from compound bacteriorhodopsin periplasmic binding protein. Many investigations focus on fine shaping classification. Here, we briefly discuss dynamic mechanism perspective classification, diversification conservation.