Characterization of Metabolically Unhealthy Overweight/Obese African American Women: Significance of Insulin-Sensitive and Insulin-Resistant Phenotypes

摘要: BACKGROUND Obesity is often associated with high cardiovascular disease risk factors. common in African American women. We investigated the characteristics of metabolically healthy and unhealthy overweight/obese women based on presence insulin resistance. MATERIALS/METHODS studied 196 apparently family history type 2 diabetes. Waist circumference, fasting glucose, insulin, c-peptide, lipids lipoproteins, systolic diastolic blood pressure were obtained each subject. In addition, sensitivity was calculated using Bergman's Minimal Model Method. defined insulin-sensitive as individuals greater than 2.7 x 10(-4) min(-1) (uU/ mL)(-1) resistant, less (uU/mL)(-1). RESULTS Thirty-three percent our subjects women, while 67% The significantly younger obese subgroup. Mean serum c-peptide lower (P = .001) subjects. However, mean pressures within normal both subgroups. cholesterol (p < .05) triglyceride levels lower, whereas high-density lipoprotein .03) higher found 25.5% had metabolic syndrome (30.3% 15.6% healthy). CONCLUSION concluded that: (1) despite obesity, appear to be prone diabetes (2) view prevalence syndrome, should targeted for primary prevention disease.