Metabolic syndrome in nondiabetic, obese, first-degree relatives of African American patients with type 2 diabetes: African American triglycerides-HDL-C and insulin resistance paradox.

作者: Kwame Osei , Trudy Gaillard , Dara Schuster , Sophia Boudoulas Meis

DOI: 10.13016/MNAB-L8KN

关键词: Waist–hip ratioInsulin resistanceDiabetes mellitusType 2 diabetesInternal medicineEndocrinologyMetabolic syndromeBody mass indexMedicineObesityFirst-degree relatives

摘要: Objective: Metabolic syndrome (MetS) defines cardiovascular disease (CVD) risks. Despite higher rates of obesity, type 2 diabetes, and hypertension, African Americans have lower MetS when compared to Caucasians, which is paradoxical, since are more insulin resistant morbidity mortality White Americans. We hypothesized that genetic inheritance predisposes the greater risk associated mortality. Therefore, we investigated prevalence components in obese, glucose-tolerant, first degree relatives American patients with diabetes. Methods: examined clinical metabolic characteristics 201 first-degree (159 females 42 males, mean age 41 6 8 years, body mass index (BMI) 32 (kg/m2). The subjects were categorized according Adult Treatment Panel (ATP) III criteria. Insulin sensitivity (Bergman minimal model method) resistance (homeostasis assessment [HOMA]) determined. without MetS. Where appropriate, our sample those data National Health Nutrition Evaluation Survey (NHANES) III. Results: Comparing group (n565) vs control (n5136), age, BMI, percent fat group. Mean fasting serum glucose, C-peptide levels also (HOMA-IR) was (HOMA-IR: 3.7 2.7 2.2 1.7, P5.0002). tended be (2.16 2.64 2.82 2.31, P5.08). In addition, despite moderately severe resistance, had very low triglyceride parameter least likely meet ATP cutoff points for criteria much Of five criteria, waist circumference single most common found 29% women 40% men 20.9% 13.9% NHANES Conclusion: that: 1) a subgroup who diabetes than III; 2) rather parameters important relatives.

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