Women Epidemiology Lung Cancer (WELCA) study: reproductive, hormonal, occupational risk factors and biobank

摘要: Lung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist women. Here we present the rationale, design organization of WELCA study (Women Epidemiology CAncer) that has launched to investigate lung women, focusing particularly on hormonal occupational factors. is a population based case-control planned recruit 1000 cases controls three years, power calculation. Eligible are female patients newly diagnosed with cancer, living Paris Ile de France area aged up 75 years. Almost all Parisian pneumology oncology departments involved. The control group random sample same area, frequency-matched age additionally stratified distribution socio-professional categories women residing there. After acquisition written consent, research nurses administer standardized computer assisted questionnaires subjects face-to-face interviews acquire anthropometric measures. Besides usual socio-demographic characteristics, information gathered about menstrual reproductive factors, treatments, lifestyle leisure history, personal familial medical history. Biological samples also collected, order establish biobank for molecular epidemiology studies. Molecular characteristics tumours will be obtained followed five years. aims answer key questions specifically role impregnation investigated, interactions cigarette smoking or body mass index (BMI) analyzed detail. history carefully reconstructed, particular service sector. creation collection serum, plasma, DNA tumour tissue allow genetic biochemical characterization both subjets tumours. follow-up help disentangling survival.